Biology Lesson

Building Life's Molecules: Macromolecules, Enzymes & Biochemical Reactions

Shared by A STEM Educator

9th Grade5E Model50 min
Learning Objective

Students will be able to distinguish the structure and biological function of carbohydrates, lipids, proteins, and nucleic acids; model dehydration synthesis and hydrolysis; and explain enzyme action and the effects of temperature and pH on reaction kinetics using lock-and-key and induced-fit models.

Lesson Overview

Students explore the four major biological macromolecules, how monomers assemble into polymers via dehydration synthesis and break apart via hydrolysis, and how enzymes catalyze reactions — including how temperature and pH affect enzyme function.

Materials

  • Paper
  • Pencils
  • Whiteboard and markers
  • Basic calculator or phone

Scaffolded Task Progression

1Task 1
The egg-fry challenge: A student claims, 'Cooking an egg just changes how it looks — the protein molecules are still exactly the same.' Do you agree or disagree? Write 1-2 sentences defending your position. (You will revisit this at the end of the lesson.)
2Task 2
Complete the paper-chain polymer lab (see Lab Blueprint). After building your chain, answer:
(a) How many water molecules were released building a 6-monomer chain?(b) How many water molecules are needed to completely break that chain back into individual monomers? Show your reasoning.

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